Dietary energy balance modulates prostate cancer progression in Hi-Myc mice.

摘要: Male Hi-Myc mice were placed on three dietary regimens [30% calorie restriction (CR), overweight control (modified AIN76A with 10kcal% fat), and a diet-induced obesity regimen (DIO) 60kcal% fat]. All diet groups had approximately similar incidence of hyperplasia low grade PIN in the ventral prostate at 3 6 months age. However, 30% CR significantly reduced situ adenocarcinomas compared to DIO group both groups. Furthermore, increased adenocarcinoma aggressive stromal invasion, as (96% vs. 65% respectively, p=0.02) month time point. Additionally, months, only carcinomas observed maintained diet. Relative control, increased, while activation Akt, mTORC1, Stat3 NFκB (p65) prostate. also (and decreased) numbers T-lymphocytes macrophages control. The mRNA levels for IL1α, IL1β, IL6, IL7, IL23, IL27, NFκB1 (p50), TNFα VEGF family members Collectively, these findings suggest that enhanced growth factor (Akt/mTORC1 Stat3) inflammatory (NFκB, cytokines) signaling may play role energy balance effects cancer progression mice.