Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature

作者: Lila Adnane , Pamela A. Trail , Ian Taylor , Scott M. Wilhelm

DOI: 10.1016/S0076-6879(05)07047-3

关键词:

摘要: … A novel class of biaryl urea that inhibits C‐RAF kinase was discovered using a combination … A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43‐9006 …

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