Mutations of the BRAF gene in benign and malignant melanocytic lesions.
作者： Amir S. Yazdi , Gabriele Palmedo , Michael J. Flaig , Ursula Puchta , Andrea Reckwerth
DOI: 10.1046/J.1523-1747.2003.12559.X
关键词:
摘要: A single-point mutation in exon 15 of the BRAF gene has recently been reported a high percentage cultured melanoma cells and 6 9 primary melanomas examined. To evaluate impact T1796A mutation, we screened melanomas, various types nevi lesions where developed an underlying nevus. We could detect 28 97 (29%) 39 187 (21%) nevi, including blue (0/20) Spitz (0/69), which did not carry mutation. In with nevus, either was present both laser-microdissected nevus (3/14) or were negative for except one case. conclusion, mutations are nonspecific progression to melanoma. Other so far unknown cofactors seem be importance.
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