High central venous pressure is associated with prolonged mechanical ventilation and increased mortality after lung transplantation

摘要: Background Poor oxygenation might occur in transplanted lungs as a result of reperfusion injury and lack lymphatic drainage. Low central venous pulmonary capillary wedge pressures are advocated to reduce edema maximize but adversely affect cardiac index, circulation, renal function. Methods Histories, intensive care unit charts, donor data on 118 lung transplantations performed between 1999 2002 were retrospectively assessed. Multiple logistic regression analysis was donor, recipient, operative, parameters determine the relationship filling pressure (central pressures) prolonged mechanical ventilation outcome. The mean used divide patients into high low groups, which then compared differences outcome complication rates. Results A found be associated with (odds ratio, 1.57; 95% confidence interval, 1.13–2.20; P = .008). After removing effect poor myocardial function by excluding index ( −1 · m −2 ) inotrope requirement (>10 μg/min), remained 2.31; 1.31–4.07; .004). Duration .02), hospital mortality .09), 2-month .02) higher greater than 7 mm Hg. There no evidence complications caused hypovolemia (≤7 Hg) group, who had lower requirements creatinine levels .013). Conclusions adverse outcomes after transplantation.