Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas
作者： Anna Sjödin , Dongsheng Guo , Morten Lund-Johansen , Bård Kronen Krossnes , Peer Lilleng
DOI: 10.1007/S00401-004-0972-6
关键词:
摘要: Secretoglobins are small secreted proteins, the expression of which has mostly been associated with secretory mucosal epithelia. Several secretoglobins have implicated in development various human cancers. Allelic deletions chromosome 11q13 correlates invasiveness pituitary tumors. Intriguingly, several secretoglobin genes located on 11q13; however, for most these and tumors not investigated. Antibodies specific lipophilin B (SCGB1D2, BU101) were developed used an immunohistochemical analysis a normal tissue microarray. Prominent immunoreactivity was found cells anterior pituitary. Eight nine analyzed adenomas showed reduction compared to However, there no apparent association between hormone production or tumor invasiveness. Expression eight different mRNAs adenoma cell line HP75 by highly quantitative real-time reverse transcription-PCR assays. Lipophilins C (SCGB2A1, mammaglobin B) prominently expressed No mRNA detected cells. The present report demonstrates, first time, its down-regulation adenomas.
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