Multi-layered nanogels with MMP-sheddable PEG masks: Preparation and promotion of tumor cell uptake by controlling surface characteristics.
作者： Jong Hoon Choi , Jung Seok Lee , Kyung Min Park , Jin Woo Bae , Yunki Lee
DOI: 10.1016/J.COLSURFB.2017.05.007
关键词:
摘要: We describe a facile and effective poly(ethylene glycol) (PEG) coating method that has not been used previously for decoration of nanogels. Layer-by-layer (LbL) assembly was the technique choice to introduce PEG onto surface multi-layered nanogels (MLNGs). Pegylated MLNGs were prepared simply by sequentially dispersing in solutions cationic polymer, anionic modified PEGs, each step validated measuring changes size charge. Particularly, peptide linker is cleavable matrix metalloproteinase-2 (MMP-2) tumor microenvironment introduced between layer because it known reduces uptake nanoparticles cells due its high mobility. In vitro cell studies demonstrated with MMP-cleavable PEGs enhanced particle up 3 times unmasking brushes as compared pegylated without MMP-sensitive linkers.
sci-hub.se 参考文章(39)
Dai Hai Nguyen, Jung Seok Lee, Jong Hoon Choi, Yunki Lee, Joo Young Son, Jin Woo Bae, Kihwang Lee, Ki Dong Park, Heparin nanogel-containing liposomes for intracellular RNase delivery Macromolecular Research. ,vol. 23, pp. 765- 769 ,(2015) , 10.1007/S13233-015-3093-2
Andrew P. Chapman, PEGylated antibodies and antibody fragments for improved therapy: a review Advanced Drug Delivery Reviews. ,vol. 54, pp. 531- 545 ,(2002) , 10.1016/S0169-409X(02)00026-1
Matthias P. Lutolf, Franz E. Weber, Hugo G. Schmoekel, Jason C. Schense, Thomas Kohler, Ralph Müller, Jeffrey A. Hubbell, Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nature Biotechnology. ,vol. 21, pp. 513- 518 ,(2003) , 10.1038/NBT818
Jong Hoon Choi, Ji Young Jang, Yoon Ki Joung, Myung Hee Kwon, Ki Dong Park, Intracellular delivery and anti-cancer effect of self-assembled heparin-Pluronic nanogels with RNase A. Journal of Controlled Release. ,vol. 147, pp. 420- 427 ,(2010) , 10.1016/J.JCONREL.2010.07.118
Zhichen Zhu, Svetlana A. Sukhishvili, Layer-by-layer films of stimuli-responsive block copolymer micelles Journal of Materials Chemistry. ,vol. 22, pp. 7667- 7671 ,(2012) , 10.1039/C2JM15676H
Jong Hoon Choi, Yoon Ki Joung, Jin Woo Bae, Jang Won Choi, Tran Ngoc Quyen, Ki Dong Park, Self-assembled nanogel of pluronic-conjugated heparin as a versatile drug nanocarrier Macromolecular Research. ,vol. 19, pp. 180- 188 ,(2011) , 10.1007/S13233-011-0214-4
Sara Alibeik, Shiping Zhu, John L. Brash, Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact. Colloids and Surfaces B: Biointerfaces. ,vol. 81, pp. 389- 396 ,(2010) , 10.1016/J.COLSURFB.2010.07.024
Zhuang Liu, Joshua T. Robinson, Xiaoming Sun, Hongjie Dai, PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs Journal of the American Chemical Society. ,vol. 130, pp. 10876- 10877 ,(2008) , 10.1021/JA803688X
Huansheng Dong, Tarek M. Fahmy, Su M. Metcalfe, Steve L. Morton, Xiao Dong, Luca Inverardi, David B. Adams, Wenda Gao, Hongjun Wang, Immuno-Isolation of Pancreatic Islet Allografts Using Pegylated Nanotherapy Leads to Long-Term Normoglycemia in Full MHC Mismatch Recipient Mice PLoS ONE. ,vol. 7, pp. e50265- ,(2012) , 10.1371/JOURNAL.PONE.0050265
D.S. Wishart, C.G. Bigam, A. Holm, R.S. Hodges, B.D. Sykes, 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects. Journal of Biomolecular NMR. ,vol. 5, pp. 332- 332 ,(1995) , 10.1007/BF00211764