Prinzipien der postoperativen Therapie beim Rektumkrazinom

摘要: In stage II (T3-4N0) and III (TxN1-2) rectal cancer, adjuvant radiochemotherapy improves overall survival decreases the rate of local failure compared to only surgical therapy is regarded as standard for patients with carcinoma lower intermediate rectum. (Preoperative) radiotherapy also following total mesorectal excision. Postoperative has no proven influence on distant metastasis rates or survival. therapy, continuous infusion 5-flourouracil bolus application increases long-term However, additional administration leucovorin levamisole results in increased toxicity not improved Results randomized trials new drugs such capecitabine, UFT, irinotecan, oxaliplatin are yet available. These should be used outside clinical trials. Elderly benefit from same extent younger receive radiochemotherapy, if contraindication exists.