Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion
作者： Wei Xie , Donglin Zhu , Li Ji , Minjie Tian , Chang Xu
DOI: 10.1016/J.BRAINRES.2014.05.019
关键词:
摘要: Chronic cerebral hypoperfusion (CCH) is associated with cognitive decline in aging, vascular dementia and Alzheimer׳s disease. Recently, angiotensin-(1-7) (Ang-(1-7)), one of the physiological constituents brain, was found to protect against dysfunction brain ischemia. However, effects Ang-(1-7) on CCH-induced deficits remained unknown. In present study, significantly alleviated rats subjected permanent bilateral occlusion common carotid arteries (a model CCH). This neuroprotective effect increased nitric oxide generation, attenuated neuronal loss suppressed astrocyte proliferation hippocampus. These findings demonstrate that a promising therapeutic agent for deficits.
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