Fetal DNA Clearance from Maternal Plasma Is Impaired in Preeclampsia

摘要: Background: Increased fetal DNA in maternal plasma/serum has been reported pregnancies complicated by preeclampsia. We hypothesized that impaired clearance of might contribute, at least part, to the above-mentioned phenomenon. Methods: studied 7 preeclamptic and 10 control pregnant women. All had male fetuses. Serial blood samples were obtained from before delivery 6 h postpartum. Male plasma was measured real-time quantitative PCR for SRY gene on Y chromosome. Results: The median concentrations significantly higher women than controls (521 vs 227 genome-equivalents/mL women, respectively; Mann–Whitney rank-sum test, P = 0.017). after also different between two groups (208 0 0.002). A first-order model found best describe kinetics clearance. Moreover, we observed a significant difference apparent half-lives (114 min) (28 min; 0.007). Conclusions: This study represents first documentation Such an abnormality circulating may be present other medical conditions associated with aberrations concentrations.