摘要: Differences in drug pharmacokinetics between newborn and adult mammals are reviewed. The pharmacokinetic alterations during the maturation process related to changes pattern of absorption, distribution, metabolism, renal excretion. most pronounced feature neonates vs adults is prolonged elimination half-life drugs. main factors causing delayed under-developed clearance immature metabolism Special attention has be paid central nervous system depressants drugs that extensively metabolized because they will accumulate with repeated dosing animals.
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van Gogh H, Nijmeijer Sn, van Duin Ct, van Miert As, Peters Rh, Basudde Cd, Korstanje C, Effect of trenbolone and testosterone on the plasma elimination rates of sulfamethazine, trimethoprim, and antipyrine in female dwarf goats. American Journal of Veterinary Research. ,vol. 49, pp. 2060- ,(1988)
S. McLean, M. E. Veronese, METABOLISM OF PARACETAMOL AND PHENACETIN IN RELATION TO DEBRISOQUINE OXIDATION PHENOTYPE European Journal of Clinical Pharmacology. ,vol. 40, pp. 547- 552 ,(1991) , 10.1007/BF00279967
P. De Backer, Comparative neonatal pharmacokinetics Springer, Dordrecht. pp. 161- 171 ,(1986) , 10.1007/978-94-009-4153-3_16
C. Friis, Postnatal development of renal function in goats Veterinary Pharmacology and Toxicology. pp. 57- 62 ,(1983) , 10.1007/978-94-009-6604-8_5
Martin B, Burrows Ge, Tripp Ml, Barto Pb, Comparative pharmacokinetics of antibiotics in newborn calves: chloramphenicol, lincomycin, and tylosin. American Journal of Veterinary Research. ,vol. 44, pp. 1053- ,(1983)
P. de Backer, M. G. Bogaert, Drug bioavailability in the developing ruminant Springer, Dordrecht. pp. 133- 140 ,(1983) , 10.1007/978-94-009-6604-8_13
Mevius D, Nouws Jf, Degen M, Baakman M, Vree Tb, Pharmacokinetics, metabolism, and renal clearance of sulfadiazine, sulfamerazine, and sulfamethazine and of their N4-acetyl and hydroxy metabolites in calves and cows. American Journal of Veterinary Research. ,vol. 49, pp. 1059- 1065 ,(1988)
R. Reiche, Drug disposition in the newborn Veterinary Pharmacology and Toxicology. pp. 49- 55 ,(1983) , 10.1007/978-94-009-6604-8_4
B Ketterer, H. Sies, Glutathione Conjugation: Mechanisms and Biological Significance ,(1989)
S. E. SHOAF, W. S. SCHWARK, C. L. GUARD, The effect of age and diet on sulfadiazine/trimethoprim disposition following oral and subcutaneous administration to calves. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 10, pp. 331- 345 ,(1987) , 10.1111/J.1365-2885.1987.TB00110.X