摘要: Postnatal development can affect the disposition and pharmacokinetics of drugs in man animals. Factors such as gastric pH, gastrointestinal motility, mucosal absorbing area, microbial population milk feeding are major determinants absorption process neonate. evolution body composition lead to important alterations distribution pattern newborns. Differences maturity at birth rate postnatal renal hepatic functions present various species. Therefore, variations pharmacodynamics between mammalian newborns be expected for same drug.
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