Spinal DC stimulation in humans modulates post-activation depression of the H-reflex depending on current polarity

作者: T. Winkler , P. Hering , A. Straube

DOI: 10.1016/J.CLINPH.2010.01.014

关键词:

摘要: Abstract Objective Transcranial direct current stimulation induces long-lasting changes in cortical excitability humans depending on the used. Further, transcutaneous spinal application of (tsDCS) plastic conduction properties, tested by somatosensory evoked potentials. To verify this thesis circuitry, we investigated effects tsDCS H-reflex size and post-activation depression. Methods Ten healthy subjects participated study. The H max / M ratio depression were evaluated before, at offset, 15min after anodal, cathodal or sham tsDCS. Stimulation cord (2.5mA, 0.063mA/cm 2 , 0.056C/cm ) was applied for Th11 level. Results Anodal induced a lasting decrease depression, while resulted sustained increase. Sham had no significant effects. remained unchanged throughout all conditions. Conclusion is non-invasive painless method that able to induce efficacy Ia fibre-motoneurone synapse. Significance Transcutaneous DC might be valuable new tool modulating motor pathways.

参考文章(33)
J. B. Nielsen, C. Crone, H. Hultborn, The spinal pathophysiology of spasticity--from a basic science point of view. Acta Physiologica. ,vol. 189, pp. 171- 180 ,(2007) , 10.1111/J.1748-1716.2006.01652.X
Otto D. Creutzfeldt, Gerhard H. Fromm, Hermann Kapp, Influence of transcortical d-c currents on cortical neuronal activity. Experimental Neurology. ,vol. 5, pp. 436- 452 ,(1962) , 10.1016/0014-4886(62)90056-0
Felipe Fregni, Paulo S. Boggio, Moises C. Lima, Merari J.L. Ferreira, Tim Wagner, Sergio P. Rigonatti, Anita W. Castro, Daniel R. Souza, Marcelo Riberto, Steven D. Freedman, Michael A. Nitsche, Alvaro Pascual-Leone, A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury Pain. ,vol. 122, pp. 197- 209 ,(2006) , 10.1016/J.PAIN.2006.02.023
Friedhelm Hummel, Pablo Celnik, Pascal Giraux, Agnes Floel, Wan-Hsun Wu, Christian Gerloff, Leonardo G Cohen, Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke Brain. ,vol. 128, pp. 490- 499 ,(2005) , 10.1093/BRAIN/AWH369
Filippo Cogiamanian, Maurizio Vergari, Francesca Pulecchi, Sara Marceglia, Alberto Priori, Effect of spinal transcutaneous direct current stimulation on somatosensory evoked potentials in humans Clinical Neurophysiology. ,vol. 119, pp. 2636- 2640 ,(2008) , 10.1016/J.CLINPH.2008.07.249
Pablo Rudomin, In search of lost presynaptic inhibition. Experimental Brain Research. ,vol. 196, pp. 139- 151 ,(2009) , 10.1007/S00221-009-1758-9
J. Nielsen, N. Petersen, C. Crone, Changes in transmission across synapses of Ia afferents in spastic patients Brain. ,vol. 118, pp. 995- 1004 ,(1995) , 10.1093/BRAIN/118.4.995
Jean-Charles Lamy, Isabelle Wargon, Dominique Mazevet, Zaïd Ghanim, Pascale Pradat-Diehl, Rose Katz, Impaired efficacy of spinal presynaptic mechanisms in spastic stroke patients Brain. ,vol. 132, pp. 734- 748 ,(2009) , 10.1093/BRAIN/AWN310