Predictive and Prognostic Markers in the Treatment of Metastatic Colorectal Cancer (mCRC)
作者： Sebastian Stintzing , Stefan Stremitzer , Ana Sebio , Heinz-Josef Lenz
DOI: 10.1016/J.HOC.2014.09.009
关键词:
摘要: This article clarifies prognostic and predictive markers in the treatment of colorectal cancer. Multiple chemotherapeutic drugs are approved for metastatic cancer (mCRC), but available guidelines often not helpful directing drug selections. It would be desirable to define patient populations before chemotherapy by biomarkers that predict outcome toxicities. RAS mutational evaluation remains only established biomarker analysis mCRC. BRAF mutant tumors associated with poor outcome. Chemotherapeutic combination therapies still remain most active treatments armamentarium, future trials should address need prospectively investigate validate biomarkers.
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