NRAS Mutations Are Rare in Colorectal Cancer

摘要: Activating mutations in members of the RAS oncogene family (KRAS, HRAS, and NRAS) have been found a variety human malignancies, suggesting dominant role carcinogenesis. In colon cancers, KRAS are common clearly contribute to malignant progression. The frequency NRAS their relationship with clinical, pathologic, molecular features remains uncertain. We developed validated Pyroseqencing assay detect at codons 12, 13, 61. Using collection 225 colorectal cancers from 2 prospective cohort studies, we examined between mutations, clinical outcome, other features, including mutation KRAS, BRAF, PIK3CA, microsatellite instability, CpG island methylator phenotype. Finally, whether was associated patient survival or prognosis. were detected 5 (2.2%) tended occur left-sided arising women, but did not seem be any that examined.