Clinical, histochemical, and biochemical studies of an ovarian dysgerminoma with trophoblasts and Leydig cells

摘要: Abstract A rare case of germ cell tumor with hormonal activities occurring in a 6-year-old girl normal female karyotype is reported. Urinary levels estrogens, pregnanediol, and 17-ketosteroids, especially etiocholanolone androsterone, were significantly elevated, but that 17-hydroxycorticosteroids was not. Human chorionic gonadotropin (HCG) titer also high. At operation, solid found the right ovary. The predominantly composed dysgerminoma cells admixed syncytiotrophoblast cells, which proved to have HCG monoamine oxidase activity, eosinophilic similar Leydig places. steroid biosynthetic studies vitro revealed presence 17-hydroxylase 17,20-desmolase addition 3β-ol-dehydrogenase aromatizing enzyme tissue, confirming admixture hormonally active other than trophoblasts. Although further are needed, new entity suggested by present tumor.