Chemistry of nitric oxide and related species.
作者： Martin N. Hughes
DOI: 10.1016/S0076-6879(08)36001-7
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摘要: Nitric oxide (NO) has essential roles in a remarkable number of diverse biological processes. The reactivity NO depends upon its physical properties, such as small size, high diffusion rate, and lipophilicity (resulting accumulation hydrophobic regions), also on facile but selective chemical toward variety cellular targets. undergoes reactions with oxygen, superoxide ions, reducing agents to give products that themselves show distinctive particular targets, sometimes the manifestation toxic effects, nitrosative stress. These include nitroxyl (HNO), oxides NO2/N2O4, N2O3, peroxynitrite, S-nitrosothiols (RSNO). HNO is attracting considerable attention due pharmacological which appear be distinct from those NO, may significant treatment heart failure.
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