Electrochemical Generation and Detection of Transient Concentration Gradients in Microfluidic Channels. Theoretical and Experimental Investigations.

摘要: Transient concentration gradients generated and detected electrochemically in continuous flow microchannels were investigated by numerical simulations amperometric measurements. Operating conditions including device geometry hydrodynamic regime theoretically delineated for producing of various profiles with tunable characteristics. Experiments carried out microfluidic devices incorporating a dual-channel-electrode configuration. Under these conditions, high electrochemical performance was achieved both to generate monitor their dynamics along linear microchannels. Good agreement observed between simulated experimental data validating predictions gradient properties generation conditions. These results demonstrated the capability microdevices produce situ real-time monitoring. This approach is versatile active control microfluidics microenvironments or chemical spatiotemporal resolution.