Obesity-related colon cancer: dietary factors and their mechanisms of anticancer action.

摘要: Summary 1. Overweight/obesity is an epidemic in the US as well other developed countries, affecting two-thirds of Americans and estimated 2.3 billion people worldwide. Obesity increases risk for Type 2 diabetes, cardiovascular disease cancer. For example, epidemiological studies have established a strong association between obesity colon cancer. 2. It generally accepted that metabolic changes associated with overweight/obesity, particularly abdominal adipocyte function, contribute to increased Understanding mechanisms underlying this important development preventive strategies Part these may be based on dietary factors, such vitamins, minerals (e.g. selenium), fibre, phytochemicals phenolic compounds. These anticancer nutrients counteract molecular obesity. 3. The present article reviews evidence inflammation insulin resistance induced by are mediators We also evaluate ability factors target obesity-induced and, thus, protect against