PPARα agonists up-regulate organic cation transporters in rat liver cells
作者： Sebastian Luci , Stefanie Geissler , Bettina König , Alexander Koch , Gabriele I. Stangl
DOI: 10.1016/J.BBRC.2006.09.099
关键词:
摘要: It has been shown that clofibrate treatment increases the carnitine concentration in liver of rats. However, molecular mechanism is still unknown. In this study, we observed for first time rats with peroxisome proliferator activated receptor (PPAR)-alpha agonist hepatic mRNA concentrations organic cation transporters (OCTNs)-1 and -2 which act as into cell. rat hepatoma (Fao) cells, WY-14,643 also increased OCTN-2. enzymes involved biosynthesis were not altered by PPARalpha agonists livers Fao cells. We conclude increase cells an uptake cell but biosynthesis.
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