Flying under the radar: the new wave of BCR–ABL inhibitors
作者： Alfonso Quintás-Cardama , Hagop Kantarjian , Jorge Cortes
DOI: 10.1038/NRD2324
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摘要: The introduction of the BCR–ABL kinase inhibitor imatinib mesylate (Gleevec; Novartis) revolutionized the treatment of chronic myeloid leukaemia (CML). However, most patients with CML receiving imatinib still harbour molecular residual disease and some develop resistance associated with ABL kinase domain mutations. The second-generation BCR–ABL inhibitors nilotinib (Tasigna; Novartis) and dasatinib (Sprycel; Bristol–Myers Squibb) have shown significant activity after imatinib failure in clinical trials, but still face similar obstacles …
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