Patient-derived xenografts for childhood solid tumors: a valuable tool to test new drugs and personalize treatments.
作者： P. Zarzosa , N. Navarro , I. Giralt , C. Molist , A. Almazán-Moga
DOI: 10.1007/S12094-016-1557-2
关键词:
摘要: The use of preclinical models is essential in translational cancer research and especially important pediatric given the low incidence each particular type cancer. Cell line cultures have led to significant advances biology. However, cell lines adapted growth artificial culture conditions, thereby undergoing genetic phenotypic changes which may hinder application. Tumor grafts developed mice from patient tumor tissues, generally known as patient-derived xenografts (PDXs), are interesting alternative approaches reproducing biology original tumor. This review focused on highlighting interest PDX supporting strategies personalized medicine. provides: (1) a description background cancer, (2) case (3) how can improve medicine strategies, (4) new methods increase engraftment, and, finally, (5) concluding remarks.
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