Exploratory Activity in Drosophila Requires the kurtz Nonvisual Arrestin

摘要: When Drosophila adults are placed into an open field arena, they initially exhibit elevated level of activity followed by a reduced stable spontaneous activity. We have found that the initial component arises from fly's interaction with novel arena since: (1) increased is independent handling prior to placement within (2) proportional size and (3) decay in levels requires both visual olfactory input. These data indicate active exploration major There specific requirement for kurtz nonvisual arrestin nervous system stimulated mechanically not required activity; mutants display normal average same velocities as wild-type controls. Inhibition dopamine signaling has no effect on phase either or krz1 mutants. Therefore, exploratory system, but dopamine's stimulation