Pharmacological Importance of Optically Active Tetrahydro-β-carbolines and Synthetic Approaches to Create the C1 Stereocenter

摘要: 1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been target extensive synthetic efforts due presence scaffold in numerous natural products and targets. This review briefly summarizes methods obtain C1 stereocenter concentrates on evaluating pharmacological importance C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral antitumor activities.