Vaccines for the malaria circumsporozoite protein
作者： Subramonia Pillai , Robert N. Brey , Wayne T. Hockmeyer , William R. Majarian
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摘要: The present invention is directed to attenuated strains of enteroinvasive bacteria that express a peptide or protein related an epitope the malaria parasites genus Plasmodium. bacterial which can multiply in host without causing significant disease disorder, and Plasmodium-related induces protective immune response against malaria, be used live vaccine formulations for malaria. In specific embodiments, expressed as fusion protein, example, with enterotoxin. also relates methods expression antigens fragments thereof within bacteria. particular by Salmonella spp. epitopes Plasmodium circumsporozoite proteins.
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