Pharmacogenetics of tyrosine kinase inhibitors in gastrointestinal stromal tumor and chronic myeloid leukemia.
作者： Gloria Ravegnini , Giulia Sammarini , Sabrina Angelini , Patrizia Hrelia
DOI: 10.1080/17425255.2016.1184649
关键词:
摘要: ABSTRACTIntroduction: Gastrointestinal stromal tumors (GIST) and chronic myeloid leukemia (CML) are two tumor types deeply different from each other. Despite the differences, these disorders share treatment with tyrosine kinase inhibitor imatinib. success of imatinib, response rates vary among individuals pharmacogenetics may play an important role in final clinical outcome.Areas covered: In this review, authors provide overview pharmacogenetic literature analyzing polymorphisms both GIST CML efficacy toxicity.Expert opinion: So far, several influencing pharmacokinetic determinants imatinib have been identified. However, data not yet conclusive enough to translate tests practice. context, major obstacles test validation represented by small sample size most studies, ethnicity population admixture as confounding source, u...
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