Anti-apolipoprotein A-1 autoantibodies are associated with immunodeficiency and systemic inflammation in HIV patients

摘要: Abstract Objectives To determine the existence of autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) in HIV patients and explore their association with biological features infection different inflammatory biomarkers. We also evaluated impact on CD4 + lymphocytes survival. Methods Anti-apoA-1 IgG plasma levels were assessed by ELISA 237 positive from a national prospective cohort no current lipid-lowering therapy. Results 58% found for anti-apoA-1 associated lower counts, but higher viremia systemic inflammation. Logistic regression analyses indicated that high 16-fold increased risk displaying low levels, independent RNA treatment (adjusted Odds ratio [OR]:16.1, 95% Confidence Interval [95%CI]:1.80–143.6; p = 0.01), 6-fold having detectable viremia, antiretroviral (OR:5.47; CI:1.63–18.36; p = 0.006). In vitro , induced dose time-dependent apoptosis was exposure to RNA. Conclusions patients, are CD4+ pro-inflammatory profile. can promote lymphocyte via undefined pathways.