Drinking pattern during midlife and risk of developing depression during 28 years of follow-up: A prospective cohort study

摘要: Abstract Background The long-term impact of alcohol intake in midlife on developing depression is not clear. We aimed to investigate drinking pattern during as a risk factor for 28 years follow-up. Methods used data from well characterised prospective cohort study (the Whitehall II study) 7478 men and women (70% male) aged 35 55 years, free 1985–1988, followed up regularly until 2013. Drinking was defined terms usual maximum amounts consumed within single session, total weekly volume frequency. Depression assessed using the General Health Questionnaire Subscale at multiple follow-up occasions (up eight times total). Associations between different components were estimated flexible parametric survival models. Results After adjustment confounding factors only abstaining associated with an increased observation. However, this association became non-significant after adjusting baseline self-reported health. Conclusions In community dwelling population, depression.