Establishment of a New Cell Line of Endometrioid Carcinoma of the Ovary and Its Chemosensitivity
作者： Tomokazu UMEZU , Hiroaki KAJIYAMA , Mikio TERAUCHI , Kiyosumi SHIBATA , Kazuhiko INO
DOI: 10.1111/J.1749-0774.2007.00030.X
关键词:
摘要: A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The showed a short spindle-shaped morphology continued to grow for more than 4 months without contact inhibition. doubling time approximately 15.5 h at the 10th passage. chromosome number aneuploid. IC50 values paclitaxel, cisplatin carboplatin were 26.4 ng/mL, 2.4 microg/mL 32.5 microg/mL, respectively. NOE cells expressed estrogen receptor alpha. In nude mice, we confirmed tumor formation cells. These results indicated that similar chemosensitivity properties those original might be useful in basic studies on diagnosis, treatment etiology tumors.
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