Patterns of allelic loss of synchronous adenocarcinomas of the lung.

摘要: Distinction of multiple primary lung carcinomas from intrapulmonary metastases using empiric clinical and histopathologic criteria can be difficult. Recent advances have provided several molecular markers that used for clonal analysis separate tumor nodules enhance staging subsequent treatment prognosis. To address this issue, we performed a microdissection-based allelotyping 20 cases histologically similar, pathologic stage T4 adenocarcinomas (ADCs). Loss heterozygosity (LOH) included panel 15 polymorphic microsatellite located on 1p, 3p, 5q, 9p, 9q, 10q, 17p, 22q. The size, visceral pleural angiolymphatic invasion, lymph node status, outcome, survival were assessed. Allelotypes 60 solitary non-small cell (NSCLC) (stages I-II) to define the percentage discordant LOH patterns within carcinoma would discriminate between survivors nonsurvivors. These in ADC. Two groups created: molecularly homogenous ( 40% discordances) (6 cases, 30%). Molecularly tumors more frequently associated with invasion (92% vs. 8%) (P = 0.018). Allelotype did not correlate age, gender, differentiation, survival, or outcome. Our study showed concordant genotypic profiles exist morphologically similar synchronous ADC lung.