Spindle cell tumors resected from male patients with germ cell tumors. A clinicopathologic study of 14 cases

摘要: We identified 14 male germ cell tumor patients (13 of whom had received prior chemotherapy) in distinctive neoplasms composed spindle to stellate cells set a myxoid collagenous stroma containing numerous blood vessels developed. These were cytokeratin-positive and vimentin-positive alpha-fetoprotein (AFP)-negative. Ten with low cellularity no mitoses have not recurrences, whereas four more cellular mitotically active tumors experienced either recurrences or death. recommend simple surgical excision, without additional chemotherapy, for the hypocellular, inactive cases. The transition from frankly sarcomatous areas three cases indicates that these lesions may be substratum development sarcomas some tumors. Based on their histologic appearance immunohistochemical profile, as well preceding evidence yolk sac (YST) 11 (data incomplete 3 cases), we speculate many represent overgrowth component YST is selected by chemotherapy.