The J-Curve Phenomenon and the Treatment of Hypertension

摘要: We critically appraised the medical literature to evaluate whether there is a point beyond which blood pressure reduction in hypertensive subjects no longer beneficial and possibly even deleterious. Thirteen studies that stratified cardiovascular outcomes by level of achieved treated who had been followed up for at least 1 year were critiqued four independent reviewers. Data addressing population, protocol, methodological characteristics evaluated. Studies did not show consistent J-shaped relationship between stroke, but they demonstrate cardiac events diastolic pressure. The therapeutic threshold was 85 mm Hg. conclude low levels, ie, below Hg, are associated with increased risk events. ( JAMA . 1991;265:489-495)