Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes

摘要: The mobilization of dendritic cells (DCs) from peripheral tissues is critical for the establishment T cell-dependent immune responses or tolerance, because physical interaction DCs with naive takes place in cell areas lymph nodes. autocrine/paracrine release high mobility group box 1 (HMGB1) nuclear protein by controls outcome DC–T interaction, influencing priming/Th1 polarization cells. We herein present evidence that receptor advanced glycation end products (RAGE), a multiligand member Ig superfamily cell-surface molecules acts as HMGB1, plays nonredundant role DC homing to used noninvasive imaging magnetic resonance and immunohistochemistry track after s.c. injection footpad wild-type +/+ RAGE −/− mice. Maturing expressing effectively migrated both conditions. In contrast, failed reach draining popliteal nodes mice, indicating integrity required mobilization. Thus HMGB1-RAGE pathway checkpoint maturation function candidate targeted therapies.