Growth hormone after abdominal surgery attenuated forearm glutamine, alanine, 3-methylhistidine, and total amino acid efflux in patients receiving total parenteral nutrition.

摘要: OBJECTIVE: The study clarified the effects of growth hormone treatment on forearm amino acid efflux in patients with full nutritional support after gastrointestinal surgery. SUMMARY BACKGROUND DATA: Growth attenuates net nitrogen loss surgical trauma. An increase protein synthesis has been described, whereas results regarding breakdown have conflicting. METHODS: Elective undergoing abdominal surgery were double blindly randomized to recombinant human (GH, n = 9) 24 IU or placebo (PL, 10) first 5 postoperative days. All received parenteral nutrition (nitrogen 5.7 +/- .1 g/m2, energy 1018 12 kcal/m2 (125 .7% BMR) and epidural analgesia. Amino plasma levels fluxes measured. RESULTS: second day, abolished total (GH: 170 117, PL: -785 192 nmol/100 mL/min, p .0007) due reduced losses both essential nonessential acids. Glutamine release was (13 15 vs. -137 43 .007) alanine attenuated (-61 17 -211 51 .01). 3-Methyl-histidine (-.20 .11 -.62 .09 .04). also induced decreased venous levels. CONCLUSIONS: When given treated nutrition, glutamine, 3-methylhistidine, from tissue. Alanine tissue attenuated.