An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins
作者： Jeffrey W. Cary , Valdet Uka , Zheng Han , Dieter Buyst , Pamela Y. Harris-Coward
DOI: 10.1016/J.FGB.2015.05.010
关键词:
摘要: The genome of the filamentous fungus, Aspergillus flavus, has been shown to harbor as many as 56 putative secondary metabolic gene clusters including the one responsible for production of the toxic and carcinogenic, polyketide synthase (PKS)-derived aflatoxins. Except for the production of aflatoxins, cyclopiazonic acid and several other metabolites the capability for metabolite production of most of these putative clusters is unknown. We investigated the regulation of expression of the PKS–non-ribosomal peptide synthetase …
core.ac.uk
sci-hub.se 参考文章(46)
Kenneth N. Raymond, Gertraud Müller, Berthold F. Matzanke, Complexation of iron by siderophores a review of their solution and structural chemistry and biological function Structural Chemistry. ,vol. 15, pp. 49- 102 ,(1984) , 10.1007/3-540-13099-3_2
Etta Käfer, Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Advances in Genetics. ,vol. 19, pp. 33- 131 ,(1977) , 10.1016/S0065-2660(08)60245-X
Sebastian Bergmann, Julia Schümann, Kirstin Scherlach, Corinna Lange, Axel A Brakhage, Christian Hertweck, Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans Nature Chemical Biology. ,vol. 3, pp. 213- 217 ,(2007) , 10.1038/NCHEMBIO869
Masafumi Tokuoka, Yasuyo Seshime, Isao Fujii, Katsuhiko Kitamoto, Tadashi Takahashi, Yasuji Koyama, Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae. Fungal Genetics and Biology. ,vol. 45, pp. 1608- 1615 ,(2008) , 10.1016/J.FGB.2008.09.006
J. W. Cary, G. R. OBrian, D. M. Nielsen, W. Nierman, P. Harris-Coward, J. Yu, D. Bhatnagar, T. E. Cleveland, G. A. Payne, A. M. Calvo, Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics Applied Microbiology and Biotechnology. ,vol. 76, pp. 1107- 1118 ,(2007) , 10.1007/S00253-007-1081-Y
Takayoshi Saruwatari, Fumitoshi Yagishita, Takashi Mino, Hiroshi Noguchi, Kinya Hotta, Kenji Watanabe, Cytochrome P450 as Dimerization Catalyst in Diketopiperazine Alkaloid Biosynthesis ChemBioChem. ,vol. 15, pp. 656- 659 ,(2014) , 10.1002/CBIC.201300751
Daniela Boettger, Christian Hertweck, Molecular diversity sculpted by fungal PKS-NRPS hybrids. ChemBioChem. ,vol. 14, pp. 28- 42 ,(2013) , 10.1002/CBIC.201200624
Axel A. Brakhage, Regulation of fungal secondary metabolism Nature Reviews Microbiology. ,vol. 11, pp. 21- 32 ,(2013) , 10.1038/NRMICRO2916
Łukasz Szyc, Jing Guo, Ming Yang, Jens Dreyer, Peter M. Tolstoy, Erik T. J. Nibbering, Bogusława Czarnik-Matusewicz, Thomas Elsaesser, Hans-Heinrich Limbach, The hydrogen-bonded 2-pyridone dimer model system. 1. Combined NMR and FT-IR spectroscopy study. Journal of Physical Chemistry A. ,vol. 114, pp. 7749- 7760 ,(2010) , 10.1021/JP103630W