Contrast agent-induced nephrotoxicity: role of oxidative stress and apoptosis through the mitochondrial pathway

摘要: Iodinated contrast media may lead to a sudden deterioration in renal function (Laville and Juillard 2010). Approximately 10% of all hospital-acquired cases failure are caused by agents. However, relatively little is known about the responsible mechanisms vivo. Therefore, editors happy that Carlo Briguori, Cristina Quintavalle, Francesa De Micco Gerolama Condorelli from Naples Milan Italy have contributed review molecular agent-induced nephrotoxicity (Briguori et al. 2010, this issue). Several human animal studies given strong evidence oxidative stress plays an important role agentinduced acute kidney injury. Furthermore, as caspase 9 3 activated but 8 10 not, apoptosis therefore induced via mitochondrial pathway. Since both, reactive oxygen species (Bolt Hengstler 2010; Nishimura Cederbaum 2009; Wang 2009a, b; Schumann Schug 2008; Glahn 2008) (Han Park Ogata Plottner Borza Lehmann 2010) represent cutting-edge topics our journal, current be high interest readers. Moreover, authors reviewed 17 clinical on prophylaxis nephrotoxicity. As result, they conclude oral treatment with potent antioxidant N-acetylcysteine appears eVective preventing failure.