Ethnic Variation in the Thymidylate Synthase Enhancer Region Polymorphism Among Caucasian and Asian Populations
作者： Sharon Marsh , Elaina S.R. Collie-Duguid , Tao Li , Xiehe Liu , Howard L. McLeod
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摘要: Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected vitro expression levels gene. We evaluated influence ethnicity on TSER genotype. Allele frequency similar Caucasian Southwest Asian subjects. However, homozygous triple subjects were twice as common Chinese (67%) than (38%). This demonstrates significant ethnic gene regulatory element which may have impact pyrimidine homeostasis drug therapy.
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C G Leichman, H J Lenz, L Leichman, K Danenberg, J Baranda, S Groshen, W Boswell, R Metzger, M Tan, P V Danenberg, Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. Journal of Clinical Oncology. ,vol. 15, pp. 3223- 3229 ,(1997) , 10.1200/JCO.1997.15.10.3223
Raunio H, Hoffman Sm, Mohrenweiser H, Huang Jd, Rautio A, Fernandez-Salguero P, Evans We, Cholerton S, Pelkonen O, A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. American Journal of Human Genetics. ,vol. 57, pp. 651- 660 ,(1995)
Y M Rustum, A Harstrick, S Cao, U Vanhoefer, M B Yin, H Wilke, S Seeber, Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. Journal of Clinical Oncology. ,vol. 15, pp. 389- 400 ,(1997) , 10.1200/JCO.1997.15.1.389
Luca L Cavalli-Sforza, The DNA revolution in population genetics. Trends in Genetics. ,vol. 14, pp. 60- 65 ,(1998) , 10.1016/S0168-9525(97)01327-9
Nobuyuki Horie, Hideo Aiba, Katsuhiko Oguro, Hiroatsu Hojo, Keiichi Takeishi, Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase Cell Structure and Function. ,vol. 20, pp. 191- 197 ,(1995) , 10.1247/CSF.20.191
Nobuyuki Horie, Keiichi Takeishi, Identification of Functional Elements in the Promoter Region of the Human Gene for Thymidylate Synthase and Nuclear Factors That Regulate the Expression of the Gene Journal of Biological Chemistry. ,vol. 272, pp. 18375- 18381 ,(1997) , 10.1074/JBC.272.29.18375
E. S.R. Collie-Duguid, Pritchard, Powrie, J. Sludden, Collier, T. Li, H. L. McLeod, The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations. Pharmacogenetics. ,vol. 9, pp. 37- 42 ,(1999) , 10.1097/00008571-199902000-00006
Tao Li, Homero Vallada, David Curtis, Maria Arranz, Ke Xu, Guiqing Cai, Hong Deng, Jun Liu, Robin Murray, Xiehe Liu, David A Collier, Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder. Pharmacogenetics. ,vol. 7, pp. 349- 353 ,(1997) , 10.1097/00008571-199710000-00002
M. F. Hammer, T. Karafet, A. Rasanayagam, E. T. Wood, T. K. Altheide, T. Jenkins, R. C. Griffiths, A. R. Templeton, S. L. Zegura, Out of Africa and back again: nested cladistic analysis of human Y chromosome variation. Molecular Biology and Evolution. ,vol. 15, pp. 427- 441 ,(1998) , 10.1093/OXFORDJOURNALS.MOLBEV.A025939
Sumiko Kaneda, Keiichi Takeishi, Dai Ayusawa, Kimiko Shimizu, Takeshi Seno, Sidney Altman, Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA Nucleic Acids Research. ,vol. 15, pp. 1259- 1270 ,(1987) , 10.1093/NAR/15.3.1259