Radiotherapy for benign head and neck paragangliomas: A 45-year experience

摘要: BACKGROUND Paragangliomas of the head and neck are rare, slow-growing, generally benign tumors neuroendocrine cells associated with peripheral nervous system that commonly involve carotid body, jugular bulb, vagal ganglia, temporal bone. Treatment options include surgery, radiotherapy (RT), stereotactic radiosurgery (SRS), observation. This article briefly reviews our 45-year institutional experience treating this neoplasm RT. METHODS From January 1968 through March 2011, 131 patients 156 paragangliomas bone, or glomus vagale were treated RT at a median dose 45 Gy in 25 fractions. The mean follow-up times 11.5 years 8.7 years, respectively. RESULTS Five (3.2%) recurred locally after RT, all within 10 treatment. overall local control rates 5 99% 96%, respectively. cause-specific survival 98% 97%, distant-metastasis free 99%, 91% 72%, There no severe complications. CONCLUSION RT for is safe efficacious treatment minimal morbidity. Surgery reserved good health whose risk morbidity low. SRS may be suitable skull base <3 cm where logistically unsuitable. Observation reasonable option asymptomatic limited life expectancy. Cancer 2014;120:3738–3743. © 2014 American Society.