Long-term results of irradiation for paraganglioma

摘要: Purpose: The management of paragangliomas is controversial. Observation, surgery, external-beam radiotherapy (EBRT), and stereotactic radiosurgery (SRS) may, alone or in combination, be appropriate, depending on the size extent tumor, previous treatment, patient age, general health, neurologic condition. Few data exist regarding long-term tumor control late effects after EBRT SRS. Methods Materials: We performed a retrospective review all patients treated with SRS for paraganglioma at our institution between 1967 1994. endpoints study were complications. Results: 33 this had median follow-up 13 years (range, 4 months to 36 years). 10-year rate was 92% (95% confidence interval, 75–98%). At last visit, no developed radiation-induced malignancy. Conclusion: External-beam RT are safe effective enlarging and/or symptomatic paragangliomas. risk developing delayed malignancy low. This must weighed against significant immediate permanent cranial nerve deficits if untreated surgically resected. also but low surgical mortality.