Glycogen-graft-poly(2-alkyl-2-oxazolines) – the new versatile biopolymer-based thermoresponsive macromolecular toolbox
作者： Aneta Pospisilova , Sergey K. Filippov , Anna Bogomolova , Stuart Turner , Ondrej Sedlacek
DOI: 10.1039/C4RA10315G
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摘要: This study is focused on thermoresponsive glycogen-graft-poly(2-alkyl-2-oxazolines), a new group of nanostructured hybrid dendrimeric stimuli-responsive polymers connecting the body’s own biodegradable polysaccharidic dendrimer glycogen with widely tuneable behavior polypeptide-analogic poly(2-alkyl-2-oxazolines), which are known to be biocompatible. Glycogen-graft-poly(2-alkyl-2-oxazolines) were prepared by simple one-pot two-step procedure involving cationic ring-opening polymerization 2-alkyl-2-oxazolines followed termination living ends sodium glycogenate. As confirmed light and X-ray scattering, as well cryo-transmission electron microscopy, grafted structure allows easy adjustment cloud point temperature, concentration dependence nanostructure self-assembled phase separated polymer crosstalk during graft composition, length grafting density, in very wide range.
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