Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey.

摘要: Abstract Objective We aimed to evaluate the frequency of chromosomal aberrations and mutations in k-ras or Her-2/neu genes surgical specimens endometrial carcinoma their association with clinicopathological findings. Materials methods Fifty-four patients who were treated for cancer between April 2010 May 2011 at Kocaeli University Obstetrics Gynecology Department, Kocaeli, Turkey enrolled a prospective study. Clinical histopathological findings recorded. Genetic analysis, which included detection deletions duplications, as well mutations, was performed on samples from specimens. Results In 70% cases, tumor size >2 cm covered entire uterine cavity, affecting mostly corpus (76%) invading less than half myometrium (80%). Forty-six cases (86%) had endometrioid-type carcinoma, early stage (Stage I, 65%) higher grade (Grade II–III, 66%) tumors predominant. Lymph node lymphovascular involvement positive 11% 28% patients, respectively. Chromosomal (deletion duplication) encountered 44%, 15%, 13% specimens, The most common aberration dup(1q) ( n  = 16). Oncogenic no severity cancer, but presence aberrations, whole alone, associated size, deeper myometrial invasion, advanced grade, lymph p Conclusion particularly dup(1q), are related disease cancer. analysis tissues may provide important insights determining prognosis.