Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles

摘要: Sutures are traumatic to soft connective tissues, such as liver or lungs. Polymer tissue adhesives require complex in vivo control of polymerization cross-linking reactions and currently suffer from being toxic, weak, inefficient within the wet conditions body. Herein, we demonstrate using Stober silica iron oxide nanoparticles that nanobridging, is, adhesion by aqueous nanoparticle solutions, can be used in rats achieve rapid strong closure healing deep wounds skin liver. Nanoparticles were also fix polymer membranes tissues even presence blood flow, occurring after resection, yielding permanent hemostasis a minute. Furthermore, medical devices engineering constructs fixed organs beating heart. The simplicity, rapidity, robustness nanobridging bode well for clinical applications, surgery, regenerative medicine.