Hypovitaminosis D: a novel risk factor for coronary heart disease in type 2 diabetes?

摘要: Vitamin D (25(OH)D) levels have been associated with cardiovascular disease. Thus, the aim of our study was to investigate association 25(OH)D coronary heart disease (CHD) in 698 consecutive type 2 diabetic outpatients. outpatients (25.2 % men, age 66 ± 9 years) and 100 (90 65 13 age-matched non-diabetic volunteers were enrolled. assay main risk factors explored. concentration 22 10 ng/ml control subjects 18.23 patients (p < 0.01). The prevalence hypovitaminosis higher than vs. 83 %, p Diabetic had high values A1C 0.01), BMI LDL cholesterol triglycerides glycemia 0.01) their vitamin D-sufficient counterparts. HDL lower while systolic diastolic blood pressure diabetes duration fibrinogen total CHD without CHD. At logistic regression analysis, lost, sex = 0.026), 0.023), 0.024) most powerful predictors current demonstrates that does not a direct effect on but may an indirect mediated by such as duration, age, sex.