Cold-inducible protein RBM3 protects neuroblastoma cells from retinoic acid-induced apoptosis via AMPK, p38 and JNK signaling

作者: Shuang-Ping Ma , Fei Ju , Ya-Ping Zhang , Xiang Shi , Rui-Juan Zhuang

DOI: 10.1016/J.JFF.2017.05.045

关键词:

摘要: Abstract As a result of vitamin A abuse, excessive retinoic acid can induce apoptosis in neural cells. Mild-hypothermia and cold-inducible protein RBM3 protect cells from apoptosis. However, whether hypothermia/RBM3 acid-induced remains unclear. The SH-SY5Y neuroblastoma cell line, common model apoptosis, was employed here. Interestingly, overdose induced cells, which prevented by mild-hypothermia. When silenced, hypothermia-related protection completely abolished. overexpression significantly Screening signaling pathways revealed that markedly inhibited upregulation p38 JNK signaling, antagonized downregulation AMPK signaling. Subsequent assays demonstrated were pro-apoptotic, while anti-apoptotic. Overall, these data showed mild-hypothermia protects via induction RBM3, subsequently mediates the neuroprotective effects AMPK,

参考文章(51)
Sandra Horschitz, Friederike Matthäus, Anja Groß, Jan Rosner, Marta Galach, Wolfgang Greffrath, Rolf-Detlef Treede, Jochen Utikal, Patrick Schloss, Andreas Meyer-Lindenberg, None, Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons. Stem Cell Research. ,vol. 15, pp. 30- 41 ,(2015) , 10.1016/J.SCR.2015.04.007
Zai-Yun Long, Ya-Min Wu, Bo-Tao Tan, Sen Li, Yuan Liu, Li Wang, Retinoic acid induced the differentiation of neural stem cells from embryonic spinal cord into functional neurons in vitro. International Journal of Clinical and Experimental Pathology. ,vol. 8, pp. 8129- 8135 ,(2015)
Jingcheng Zhang, Yang Gao, Mengying Yu, Haibo Wu, Zhiying Ai, Yongyan Wu, Hongliang Liu, Juan Du, Zekun Guo, Yong Zhang, Retinoic Acid Induces Embryonic Stem Cell Differentiation by Altering Both Encoding RNA and microRNA Expression PLOS ONE. ,vol. 10, pp. e0132566- ,(2015) , 10.1371/JOURNAL.PONE.0132566
MARCOS ROBERTO DE OLIVEIRA, The neurotoxic effects of vitamin A and retinoids. Anais Da Academia Brasileira De Ciencias. ,vol. 87, pp. 1361- 1373 ,(2015) , 10.1590/0001-3765201520140677
Yi-Qiao Xing, An-Huai Yang, Yao-Peng Xu, Wei Jin, In vitro induction and differentiation of umbilical cord mesenchymal stem cells into neuron-like cells by all-trans retinoic acid. International Journal of Ophthalmology. ,vol. 8, pp. 250- 256 ,(2015) , 10.3980/J.ISSN.2222-3959.2015.02.07
Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A. Moreno, Joern R. Steinert, Tim Smith, David Dinsdale, Anne E. Willis, Giovanna R. Mallucci, RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration Nature. ,vol. 518, pp. 236- 239 ,(2015) , 10.1038/NATURE14142
Mariko Tsukane, Takashi Yamauchi, Increase in apoptosis with neural differentiation and shortening of the lifespan of P19 cells overexpressing tau Neurochemistry International. ,vol. 48, pp. 243- 254 ,(2006) , 10.1016/J.NEUINT.2005.09.008
Courtney L. Robertson, Susanna Scafidi, Mary C. McKenna, Gary Fiskum, Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Experimental Neurology. ,vol. 218, pp. 371- 380 ,(2009) , 10.1016/J.EXPNEUROL.2009.04.030
J. Dresios, A. Aschrafi, G. C. Owens, P. W. Vanderklish, G. M. Edelman, V. P. Mauro, Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 1865- 1870 ,(2005) , 10.1073/PNAS.0409764102