作者: Shuang-Ping Ma , Fei Ju , Ya-Ping Zhang , Xiang Shi , Rui-Juan Zhuang
DOI: 10.1016/J.JFF.2017.05.045
关键词:
摘要: Abstract As a result of vitamin A abuse, excessive retinoic acid can induce apoptosis in neural cells. Mild-hypothermia and cold-inducible protein RBM3 protect cells from apoptosis. However, whether hypothermia/RBM3 acid-induced remains unclear. The SH-SY5Y neuroblastoma cell line, common model apoptosis, was employed here. Interestingly, overdose induced cells, which prevented by mild-hypothermia. When silenced, hypothermia-related protection completely abolished. overexpression significantly Screening signaling pathways revealed that markedly inhibited upregulation p38 JNK signaling, antagonized downregulation AMPK signaling. Subsequent assays demonstrated were pro-apoptotic, while anti-apoptotic. Overall, these data showed mild-hypothermia protects via induction RBM3, subsequently mediates the neuroprotective effects AMPK,