MicroRNA control of Nodal signalling.

摘要: MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors growth factor signalling is largely unknown. Ligands the transforming factor-β superfamily essential for development and adult tissue homeostasis. In early Xenopus embryos, by ligand Nodal dorsal induction Spemann’s organizer. Here we report that laevis microRNAs miR-15 miR-16 restrict size organizer targeting type II receptor Acvr2a. Endogenous ventrally enriched they negatively regulated Wnt/β-catenin pathway. These findings exemplify relevance regulators embryonic patterning acting at crossroads fundamental cascades. The generation a central event in embryology. Commonly called Spemann's organizer, this collection cells induced on side developing embryo an asymmetry Nodal, β ligand. Little known about nature asymmetry. Now Martello et al. show involved process. Two microRNAs, miR-16, generating bias expression small single-stranded RNA molecules help regulate expression; many diverse functions only just beginning to be fully explored. This new work shows act phase patterning, provide missing link between β-catenin signalling. Generation signalling, which sufficiently high dorsally induce organizer-specific expression. Now, through identification microRNA (miR-15 miR-16) targets receptor, shown have role