Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men.

摘要: Background: Trials of testosterone therapy in aging men have demonstrated increases fat-free mass (FFM) and skeletal muscle decreases fat (FM) but not reported the impact baseline body composition. Objective: The objective study was to determine effect, nonobese with symptoms androgen deficiency low-normal serum levels, on total regional composition hormonal metabolic indices. Methods: Sixty healthy symptomatic, aged 55 yr or older (TT) levels less than 15 nm were randomized transdermal patches placebo for 52 wk. Body composition, by dual-energy x-ray absorptiometry (FM, FFM, muscle) magnetic resonance imaging (abdominal sc visceral adipose tissue, thigh muscle, intermuscular fat) parameters measured at wk 0 52. Results: Serum TT increased 30% (P = 0.01), LH decreased ...