Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases.

作者: Daniela Massi , Alessandro Franchi , Llucia Alos , Martin Cook , Silvana Di Palma

DOI: 10.1111/J.1365-2559.2009.03471.X

关键词:

摘要: Massi D, Franchi A, Alos L, Cook M, Di Palma S, Enguita A B, Ferrara G, Kazakov D V, Mentzel T, Michal Panelos J, Rodriguez-Peralto J Santucci Tragni Zioga & Tos P D (2010) Histopathology56, 251–262 Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases Aims:  Cutaneous leiomyosarcomas (LMS) are rare in comparison with their deep-seated soft tissue and uterine counterparts, have been poorly characterized. The aim was to verify whether the clinical behaviour purely dermal LMS is different from that minimal subcutis invasion. Methods results:  Twenty-one 15 extension were analysed. Tumours developed 27 men nine women (age range 29–91 years); most tumours showed a fasciculated (n = 23), pilar-type (n = 12) pleomorphic (n = 1) pattern. During follow-up period (range 2–192, mean 41 months) recurrences occurred 1/16 (6.2%) confined dermis 2/11 (18.1%) extension. three recurrent high-grade LMS, two which exhibited myxoid areas. One patient into fat distant metastases 15 years after diagnosis. Conclusions:  For involving skin, it advisable recognize indicate histopathology report depth and/or subcutaneous extension, since even involvement may be associated late local metastases, therefore appropriate long-term needed.

参考文章(31)
A Spatz, J Genin, A Margulis, G Contesso, S Auroy, A Lecesne, M F Avril, [Primary cutaneous leiomyosarcoma: 32 cases]. Annales De Dermatologie Et De Venereologie. ,vol. 126, pp. 235- 242 ,(1999)
John E. Karroum, Eugene G. Zappi, Clay J. Cockerell, Sclerotic primary cutaneous leiomyosarcoma. American Journal of Dermatopathology. ,vol. 17, pp. 292- 296 ,(1995) , 10.1097/00000372-199506000-00013
Lori L. Davidson, Marc L. Frost, C. William Hanke, Warren W. Epinette, Primary leiomyosarcoma of the skin Journal of the American Academy of Dermatology. ,vol. 21, pp. 1156- 1160 ,(1989) , 10.1016/S0190-9622(89)70322-4
Robert A. Wascher, Margaret Y. T. Lee, Recurrent cutaneous leiomyosarcoma. Cancer. ,vol. 70, pp. 490- 492 ,(1992) , 10.1002/1097-0142(19920715)70:2<490::AID-CNCR2820700218>3.0.CO;2-F
Marianne Lidang Jensen, Olaf Myhre Jensen, Wojchiech Michalski, Ole Steen Nielsen, Johnny Keller, Intradermal and subcutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 41 cases. Journal of Cutaneous Pathology. ,vol. 23, pp. 458- 463 ,(1996) , 10.1111/J.1600-0560.1996.TB01435.X
Orli Wargon, Primary leiomyosarcoma of the skin Australasian Journal of Dermatology. ,vol. 38, pp. 26- 28 ,(1997) , 10.1111/J.1440-0960.1997.TB01094.X
NICOLE M. ANNEST, SARAH J. GREKIN, MARY SEABURY STONE, MICHAEL J. MESSINGHAM, Cutaneous Leiomyosarcoma: A Tumor of the Head and Neck Dermatologic Surgery. ,vol. 33, pp. 628- 633 ,(2007) , 10.1111/J.1524-4725.2007.33124.X
Jochen Utikal, Georg Haus, Nina Poenitz, Wolfgang Koenen, Walter Back, Edgar Dippel, Alexei Gratchev, Sergij Goerdt, None, Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms Journal of Cutaneous Pathology. ,vol. 33, pp. 20- 23 ,(2006) , 10.1111/J.1600-0560.2006.00491.X
Gerard V. Aranha, Zelma V. Molnar, Cesar V. Reyes, Gregory Skladzien, Virginia T. Valadka, Leiomyosarcoma of the skin: A case report Journal of Surgical Oncology. ,vol. 19, pp. 87- 89 ,(1982) , 10.1002/JSO.2930190208