EBP50 interacts with EGFR and regulates EGFR signaling to affect the prognosis of cervical cancer patients

摘要: Abstract Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) has a role in the occurrence and progression of multiple types tumors. However, its cervical cancer (CC) remain unknown. EBP50 was reported to interact with epidermal growth factor receptor (EGFR) regulate EGFR signaling CC HeLa cells. In this study, effect expression on cell proliferation prognosis patients by regulating investigated. We found that level significantly downregulated tissues. negatively correlated proliferation, cycle activation EGFR-mediated ERK signaling. knockdown abolished inhibition EGF-induced activation, suggesting regulated order further explore via interaction, we constructed EBP50_DD mutant which disrupted interaction EGFR. overexpression attenuated EBP50_WT signaling, revealing associated poor patients. could not predict all after ruling out egfr/ErbB mutation or copy number variation (CNV) (chemo)radiation, caused continuous affected patients, respectively, exhibited prediction ability, conclusion, played an important interacting might be potential precise therapeutic target prognostic marker for