The battle for iron in enteric infections

摘要: Iron is an essential element for almost all living organisms, but can be extremely toxic in high concentrations. All organisms must therefore employ homeostatic mechanisms to finely regulate iron uptake, usage and storage the face of dynamic environmental conditions. The critical step mammalian systemic homeostasis fine regulation dietary absorption. However, as gastrointestinal system also home >1014 bacteria, which engage their own programmes homeostasis, gut represents anatomical location where inter-kingdom fight never-ending. Here, we explore molecular of, interactions between, host bacterial tract. We first detail how cellular influences availability. then focus on two important human pathogens, Salmonella Clostridia; despite differences, they exemplify a pathogen navigate exploit this web avoid nutritional immunity replicate successfully. reciprocally availability interacts with microbiota, consequences physiology acquisition. Finally, address understanding battle tract might inform clinical practice inspire new treatments diseases.