Risk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients

摘要: Family relatives of gastric cancer patients have a higher risk and premalignant lesions. We sought to determine the factors associated with presence intestinal metaplasia in large cohort relatives. First-degree were invited for screening gastroscopy. Endoscopic biopsies obtained from antrum corpus. Gastric analyzed Helicobacter pylori infection, severity inflammation, metaplasia. Stepwise logistic regressions used identify Two hundred seventy underwent endoscopy (median age, 42; 47% male 48% siblings). Among them, 161 (59.6%) H. positive 81 (30%) had confirmed The following found be metaplasia: sex, birth order, alcohol use, siblings stomach cancer, childhood living conditions, water supply. Individuals more severe acute chronic inflammation corpus (P < 0.003). With multiple regression, infection [odds ratio (OR), 3.23], gender (OR, 2.09), age 1.07), history 1.91) independent development In conclusion, we identified relatives, which may useful understanding carcinogenesis these high-risk individuals.