Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells.
作者： Garret L. Yount , Daphne A. Haas-Kogan , Kiera S. Levine , Mark A. Israel , Hiroko Kuriyama
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摘要: Radiation-induced apoptosis can be mediated through pathways initiated by either DNA damage or ceramide-induced Fas signaling. Glioblastoma multiforme is a primary brain tumor that highly resistant to irradiation, and U-87 MG, SF126, T98G are glioblastoma-derived cell lines mimic this characteristic. We found these radioresistant glioma cells susceptible Fas-mediated death induced treatment with anti-Fas antibody exogenous ceramide. in p53-independent. These data demonstrate ceramide the pathway cells, although high-dose ionizing radiation fails trigger pathway.
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